Smart Reactors

Camouflage™ Technology

Camouflage™ Inert Surface

Camouflage™ technology is a proprietary coating technology incorporating a synthetic polymer combined with a proteinaceous base layer. The coating technology is non-toxic, demonstrates excellent hemocompatibility, and endotheliazation.  It is designed to reduce clotting cascade initiation and provides long term stability for use on a range of blood contacting medical devices. Camouflage™ is underpinned by solid Intellectual property (IP) to differentiate and to create value for our customers. ​

Camouflage™ acts by retaining a layer of the patient's non-inflammatory proteins (red blood cells and blood components) on the coating. This hemocompatible coating masks the device surface from the circulating blood, reducing the body's reaction to the foreign material. It also promotes endothelization, supporting the attachment of endothelial cells for long-term biocompatibility. Additionally, the antimicrobial properties of the coating help prevent infection, ensuring a safer and more durable implant.

Benefits of Camouflage™

Excellent Surface Performance

Camouflage™ coating technology demonstrates superior hemocompatible performance with add endothelialization properties for a range of blood contacting devices.

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Adheres to many Substrates

Camouflage™ coating is a versatile coating that adheres to many substrates.

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Ultra Thin Coating

Camouflage™ coating is a superior thin coating, colourless to the naked eye.

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Long Term Durability

Camouflage™ coating demonstrates longer term durability on a range of devices.

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Non-Medicinal Polymer

Camouflage™ coating technology is a non-medicinal polymer.

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Manufacturing Process

Camouflage™ coating technology is easy to integrate into manufacturing process.

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Camouflage™ Hemcompatibility Testing Results

At Smart Reactors, our Camouflage™ coatings are engineered to deliver superior performance in hemocompatibility and promotion of endothelialization growth. To validate these claims, our Research & Development team conducted a series of hemocompatibility tests, comparing Camouflage™ against both phosphorylcholine and albumin coatings. The results demonstrate the exceptional capabilities of Camouflage™ in providing optimal performance across key coagulation pathways.

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Excellent Hemocompatibility & Endotheliazation Performance

Camouflage™ Coating demostartes excellent hemocompatibility and endothelialization performance as shown in the results  below;

SEM Images

Endotheliazation-Nitinol Stents

Endothelialization- Cell viability

Viability of cells on coated and uncoated NiTi stents after 1hr semi-dynamic incubation and after 29hr static incubation. 

Biocidal Properties- Contact & Recovery

Evaluation according ti USP<1072> Disinfectant and Antiseptics. 1Hr. contact with coating and evaluation of reduction of culture counts vs controls. 

  • 2.1 log (99%) reduction in E. coli
  • 2.5 log (99.7%) reduction in P. aeruginosa
  • 1.7 log (97.7%) reduction in C. albicans
  • 0.7 log (80%) reduction in A. brasilinensis
  • 0.6 log (73.5%) reduction in S. aureus
  • 0.2 log (49.6%) reduction in B. subtilis

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Adheres to many substrates

Camouflage coating is a versatile coating that adheres to many substrates without the need for specialist pretreatment. The coating can be applied as either a dip coating or in flow to coat all substrate geometries without the need for UV or thermal crosslinking.
 
Camouflage™ coating is versatile with most polymeric and metallic substrates, including, but not limited to, the items listed below.

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Ultra Thin Coating

Camouflage™ coating is just a few nanometres thick and is suitable for a broad range of application with the medical device space. ​

This  super thin coating does not impede gas exchange permeability on perfusion devices and is perfect positioned for implantable devices to avoid thrombus formation and endothelialisation of surfaces for long term implants

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Long Term Durability

Camouflage™ has a crosslinking chemistry which ensures that the coating matrix is durable for long term applications with covalent bonds providing stability. This crosslinking chemistry is performed in water and does not rely on Ultra-Violet or heat. This allows us to apply a durable coating on samples with complex geometries where UV light can’t reach and where thermal stability is a concern.

For perfusion applications 28 day stability was demonstrated using 37 Deg C saline in flow to simulate physiological shear stresses and all samples remained coated supporting applications such as ECMO where long term performance is key.

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Non-Medicinal Polymer

Camouflage™ coating technology does not incorporate active pharmaceutical ingredientsCamouflage™ is designed to control the interaction of the surface with the​ circulating blood and it retains non-inflammatory proteins and blood constituents​ on the surface. This interaction passivates the surface and Camouflage™ does not rely on any pharmaceutical​ mechanism of action while generating performance that is comparable to heparin in terms of thrombus reduction.​

 This simplifies the supply chain for manufacturers and provides an easier and clearer pathway to regulatory approval as it is not considered a​ combi-product and does not fall under Rule 14 of MDR.

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Manufacturing Process

Lean Manufacturing Process

  • Smart Reactors Camouflage™ coating utilizes a lean process which can be transferred into your new or existing operations with ease
  • It utilizes a water-based process with no hazardous organic solvents.
  • The process can be a dip or flow through process which services the majority of applications
  • The Crosslinking process does not require UV or Thermal curing
  • There is a Minimal Capex requirement (<€100,000)
  • Smart Reactors Technical transfer program provides all the necessary specifications/SOP’s to allow for a complete set-up of the coating process in the manufacturing site of choice.

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